Prime-editing correction of pathogenic ABCA4 variants in retinal organoids

// Where the money goes

• Personnel & stipends42% of funds

  Salaries for the funder-selected team, published quarterly

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• Reagents & consumables23% of funds

  Itemised supplier invoices for every order

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• Instrument time19% of funds

  Core-facility booking logs with hourly rates

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• Open-access publishing9% of funds

  Article processing charges so results stay free to read

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• Platform & audit fee7% of funds

  Independent quarterly audit of all spending

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// Research updates

1. This month

   Data collection underway

   Deploying a split-intein prime editor to revert Stargardt-causing mutations in patient-derived photoreceptor organoids, with single-cell readout of correction efficiency. The team is currently working through the data collection stage and posting weekly notebook entries for backers.

2. Last month

   Funder-selected team confirmed

   Backers reviewed shortlisted candidates and voted the postdoc, research engineer, and data scientist onto the project. Credentials are linked above.

3. Campaign start

   Protocol pre-registered

   The full protocol, analysis plan, and budget breakdown were registered publicly before a single dollar was spent.